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Index > Protein center > CASP7(Gene name) > Human
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  • CASP7 (Gene name),
  • Caspase-7 (Protein name ),  CASP7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CASP7(MCH3);
    Protein name:
    Caspase-7(CASP-7);
    Alternative:
    CMH-1;Apoptotic protease Mch-3;ICE-like apoptotic protease 3(ICE-LAP3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
    Function:
    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    303
    Sequence:
    50:
    MADDQGCIEE | QGVEDSANED | SVDAKPDRSS | FVPSLFSKKK | KNVTMRSIKT | 
    100:
    TRDRVPTYQY | NMNFEKLGKC | IIINNKNFDK | VTGMGVRNGT | DKDAEALFKC | 
    150:
    FRSLGFDVIV | YNDCSCAKMQ | DLLKKASEED | HTNAACFACI | LLSHGEENVI | 
    200:
    YGKDGVTPIK | DLTAHFRGDR | CKTLLEKPKL | FFIQACRGTE | LDDGIQADSG | 
    250:
    PINDTDANPR | YKIPVEADFL | FAYSTVPGYY | SWRSPGRGSW | FVQALCSILE | 
    300:
    EHGKDLEIMQ | ILTRVNDRVA | RHFESQSDDP | HFHEKKQIPC | VVSMLTKELY | 
    303:
    FSQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human CASP-7
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    ELISA Kit for Human CASP-7
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    E2266m
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    CLIA Kit for Human CASP-7
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    U2266m
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    Packing:
    96T
    CLIA Kit for Human CASP-7
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    U2266h
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    Packing:
    96T
    Polyclonal Antibody for Human CASP-7
    Cat.:
    P2266Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CASP-7
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    P2266Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CASP-7
    Monoclonal Antibody for Human CASP-7
    Protein for Human CASP-7
    Protein for Human CASP-7

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    Recovery
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    Linearity
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    References
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    6. 6.
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    7. 7.
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      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
    8. 8.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
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      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLU-4
      tissue: Skin.
    11. 11.
      "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains."
      Fernandes-Alnemri T. , Armstrong R.C. , Krebs J.F. , Srinivasula S.M. , Wang L. , Bullrich F. , Fritz L.C. , Trapani J.A. , Tomaselli K.J. , Litwack G. , Alnemri E.S.
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    13. 13.
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      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
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    15. 15.
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      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
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